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EP 4 739 191 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24836436.6 (22) Date of filing: 04.07.2024

(51) International Patent Classification (IPC):  A61B 1/05(2006.01) G01N 21/65(2006.01) A61B 5/00(2006.01) (52) Cooperative Patent Classification (CPC): G01N 21/65; G01N 21/474; G01N 21/55; G01N 2021/4742; G01N 2021/555; A61B 5/4869; A61B 5/14546; A61B 1/303; A61B 5/0084; A61B 5/0075; A61B 5/4337; A61B 5/14542 (86) International application number: PCT/SG2024/050437 (87) International publication number: WO 2025/010030 (09.01.2025 Gazette 2025/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 06.07.2023 SG 10202301934V (71) Applicants: Agency for Science, Technology and Research Singapore 138632 (SG) National University Hospital (Singapore) Pte Ltd Singapore 119228 (SG) National University of Singapore Singapore 119077 (SG)

(72) Inventors: TEO, Xinhui, Valerie Singapore 138669 (SG) UNNIMADHAVA KURUP SOUDAMINI AMMA, Dinish Singapore 138669 (SG) BALASUNDARAM, Ghayathri Singapore 138669 (SG) OLIVO, Malini Carolene Devapiriyai Singapore 138669 (SG) ZHANG, Ruochong Singapore 138669 (SG) CHOOLANI, Mahesh Singapore 119228 (SG) LOGAN, Susan Aberdeen AB24 5HY (GB) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)