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EP 4 739 307 A2

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(88) Date of publication A3: 01.05.2025 (43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24836549.6 (22) Date of filing: 02.07.2024

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/33(2006.01) A61K 31/4709(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; C07D 519/00; A61K 31/437 (86) International application number: PCT/US2024/036596 (87) International publication number: WO 2025/010291 (09.01.2025 Gazette 2025/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 03.07.2023 US 202363524837 P 14.12.2023 US 202363610275 P (71) Applicant: The General Hospital Corporation Boston, Massachusetts 02114 (US)

(72) Inventors: HAGGARTY, Stephen J. Gloucester, Massachusetts 01930 (US) ROSENTHAL, Zachary Cambridge, Massachusetts 02138 (US) MAZITSCHEK, Ralph Weston, Massachusetts 02493 (US) PATNAIK, Debasis Weymouth, Massachusetts 02191 (US) PAYNE, Neil Boston, Massachusetts 02114 (US) HOOKER, Jacob M. Belmont, Massachusetts 02478 (US) PACZEK, Michael Boston, Massachusetts 02114 (US) FASS, Daniel M. Boston, Massachusetts 02114 (US) (74) Representative: Maiwald GmbH  Engineering Elisenhof Elisenstrasse 3 80335 München 80335 München (DE)