(19)
(11) EP 4 739 310 A1

(12)

(43) Date of publication:
13.05.2026 Bulletin 2026/20

(21) Application number: 24835433.4

(22) Date of filing: 05.07.2024
(51) International Patent Classification (IPC): 
A61K 31/437(2006.01)
C07D 471/04(2006.01)
 A61K 31/444(2006.01)
A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/444; A61P 35/00; A61K 33/243; A61K 31/337; A61K 45/06
 
C-Sets:
  1. A61K 31/444, A61K 2300/00;
  2. A61K 33/243, A61K 2300/00;
  3. A61K 31/337, A61K 2300/00;
(86) International application number:
PCT/CN2024/103876
(87) International publication number:
WO 2025/007955 (09.01.2025 Gazette 2025/02)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 06.07.2023 WO PCT/CN2023/106187

(71) Applicant: Insilico Medicine IP Limited
Central (HK)

(72) Inventors:
  • CHEN, Xiaojing
    Shanghai 201203 (CN)
  • PU, Congying
    Shanghai 201203 (CN)
  • LIU, Jin
    Shanghai 201203 (CN)
  • ZHANG, Man
    Shanghai 201203 (CN)
  • CHENG, Xin
    Shanghai 201203 (CN)
  • LIU, Yingtao
    Shanghai 201203 (CN)
  • QIN, Luoheng
    Shanghai 201203 (CN)
  • REN, Feng
    Shanghai 201203 (CN)
  • YU, Huaxing
    Shanghai 201203 (CN)

(74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB 
Siebertstraße 3
81675 München
81675 München (DE)

   


(54) ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) INHIBITOR COMBINATIONS AND USES THEREOF