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EP 4 739 324 A2

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(88) Date of publication A3: 08.05.2025 (43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24840312.3 (22) Date of filing: 03.07.2024

(51) International Patent Classification (IPC):  A61K 35/22(2015.01) C12N 5/00(2006.01) C12N 5/071(2010.01) A61P 13/12(2006.01) (52) Cooperative Patent Classification (CPC): C12N 5/0686; G01N 33/5044; A61K 35/22 (86) International application number: PCT/US2024/036783 (87) International publication number: WO 2025/014766 (16.01.2025 Gazette 2025/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 07.07.2023 US 202363512541 P 12.10.2023 US 202363589934 P (71) Applicants: Bertram, Timothy, A. Grand Cayman KY1-9006 (KY) Jain, Deepak Winston-Salem, NC 27104 (US) Narayan, Prakash Winston-Salem, NC 27103 (US)

(72) Inventors: Bertram, Timothy, A. Grand Cayman KY1-9006 (KY) Jain, Deepak Winston-Salem, NC 27104 (US) Narayan, Prakash Winston-Salem, NC 27103 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)