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(11)

EP 4 739 351 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24836564.5 (22) Date of filing: 03.07.2024

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61P 9/04(2006.01) C12N 15/864(2006.01) (52) Cooperative Patent Classification (CPC): A61P 9/04; C12N 15/86; C12N 2750/14143; C12N 9/1205; A01K 67/0275; A01K 2217/075; A01K 2227/105; A01K 2267/0375; A61K 48/005; A01K 2217/072; A61K 38/45; C12Y 207/11001 (86) International application number: PCT/US2024/036646 (87) International publication number: WO 2025/010312 (09.01.2025 Gazette 2025/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 06.07.2023 US 202363512200 P (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: CHEN, Ju San Diego, California 92129 (US) FENG, Wei San Diego, California 92131 (US) (74) Representative: Berggren Oy  P.O. Box 16 Fabianinkatu 21 00101 Helsinki 00101 Helsinki (FI)