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EP 4 739 352 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24836630.4 (22) Date of filing: 05.07.2024

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61P 9/10(2006.01) C12N 15/861(2006.01) A61P 9/06(2006.01) A61K 38/16(2006.01) C07K 14/21(2006.01) (52) Cooperative Patent Classification (CPC): A61P 9/06; A61P 9/10; C07K 14/21; C12N 2750/14143; C12N 15/86; C12N 2830/008; A61K 48/005; A61K 48/0075; A61K 38/00 (86) International application number: PCT/US2024/036948 (87) International publication number: WO 2025/010423 (09.01.2025 Gazette 2025/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 05.07.2023 US 202363512038 P (71) Applicant: Duke University Durham, North Carolina 27705 (US)	(72) Inventors: BURSAC, Nenad Durham, North Carolina 27705 (US) WU, Tianyau Durham, North Carolina 27705 (US) (74) Representative: Harris, Oliver John Richard  Novagraaf UK Centrum Norwich Research Park Colney Lane Norwich NR4 7UG Norwich NR4 7UG (GB)