(19)
(11) EP 4 739 656 A1

(12)

(43) Date of publication:
13.05.2026 Bulletin 2026/20

(21) Application number: 24742983.0

(22) Date of filing: 04.07.2024
(51) International Patent Classification (IPC): 
C07D 211/54(2006.01)
C07D 401/12(2006.01)
C07D 405/12(2006.01)
C07D 413/12(2006.01)
A61K 31/453(2006.01)
A61K 31/4545(2006.01)
 C07D 401/06(2006.01)
C07D 401/14(2006.01)
C07D 405/14(2006.01)
A61K 31/445(2006.01)
A61K 31/454(2006.01)
A61P 25/04(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 211/54; C07D 405/12; C07D 401/12; C07D 413/12; C07D 401/14; C07D 405/14; C07D 401/06; A61P 25/04
(86) International application number:
PCT/FI2024/050372
(87) International publication number:
WO 2025/008574 (09.01.2025 Gazette 2025/02)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 05.07.2023 FI 20237131

(71) Applicant: Orion Corporation
02200 Espoo (FI)

(72) Inventors:
  • AHLMARK, Marko
    02101 Espoo (FI)
  • HAIKARAINEN, Anssi
    02101 Espoo (FI)
  • KOIVISTO, Ari-Pekka
    02101 Espoo (FI)
  • KUMPULAINEN, Esa
    02101 Espoo (FI)
  • SAHARI, Aleksi
    02101 Espoo (FI)
  • TURKU, Ainoleena
    02101 Espoo (FI)
  • VÄISÄNEN, Emilia
    02101 Espoo (FI)

(74) Representative: J A Kemp LLP 
80 Turnmill Street
London EC1M 5QU
London EC1M 5QU (GB)

   


(54) 2-PHENOXY-1-(4-(ALKYLSULFONYL)PIPERIDIN-1-YL)ETHAN-1-ONE AND 3-PHENYL-1-(4-(ALKYLSULFONYL)PIPERIDIN-1-YL)PROP-2-EN-1-ONE DERIVATIVES AS GPR183 ANTAGONISTS FOR THE TREATMENT OF CHRONIC PAIN