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EP 4 739 658 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24743639.7 (22) Date of filing: 05.07.2024

(51) International Patent Classification (IPC):  C07D 213/73(2006.01) C07D 513/14(2006.01) C07D 513/04(2006.01) (52) Cooperative Patent Classification (CPC): C07D 513/14; C07D 213/73; C07D 513/04 (86) International application number: PCT/US2024/036849 (87) International publication number: WO 2025/010390 (09.01.2025 Gazette 2025/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 05.07.2023 US 202363525079 P (71) Applicant: Agios Pharmaceuticals, Inc. Cambridge, MA 02139 (US)

(72) Inventors: FANDRICK, Daniel, R. Cambridge, MA 02139 (US) LEUNG, Chun Yuen Cambridge, MA 02139 (US) CRANE, Sheldon Saint-Laurent, QC H4R 2N6 (CA) LACHANCE, Nicolas Saint-Laurent, Québec H4R 2N6 (CA) LE ROUX, Antoine Saint-Laurent, Québec H4R 2N6 (CA) PATEL, Jignesh Surendrabhai Thornhill, ON L4J 0H9 (CA) VALAMALE, Ashalatha Badiadka Saint-Laurent, Québec H4R 2N6 (CA) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)