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EP 4 739 668 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24741022.8 (22) Date of filing: 03.07.2024

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) A61P 7/00(2006.01) A61K 31/4035(2006.01) C07D 495/04(2006.01) A61P 25/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/04; C07D 495/04; A61P 25/00; A61P 7/00; C07D 471/04; C07D 209/48; C07D 403/04; C07D 409/06; C07D 209/49 (86) International application number: PCT/NL2024/050360 (87) International publication number: WO 2025/014359 (16.01.2025 Gazette 2025/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 07.07.2023 NL 2035306 (71) Applicants: Academisch Ziekenhuis Leiden (h.o.d.n. LUMC) 2333 ZA Leiden (NL) Universiteit Leiden 2311 EZ Leiden (NL)	(72) Inventors: LEBRIN, Franck Patrice Gérard 2333 ZA Leiden (NL) THALGOTT, Jérémy Hervé 2333 ZA Leiden (NL) DEKKERS, Sebastian 2333 ZA Leiden (NL) IJZERMAN, Adriaan 2311 EZ Leiden (NL) (74) Representative: HGF  HGF BV Benoordenhoutseweg 46 2596 BC The Hague 2596 BC The Hague (NL)