(19)
(11) EP 4 739 681 A1

(12)

(43) Date of publication:
13.05.2026 Bulletin 2026/20

(21) Application number: 24835340.1

(22) Date of filing: 02.07.2024
(51) International Patent Classification (IPC): 
C07D 417/14(2006.01)
A61K 31/381(2006.01)
A61P 35/00(2006.01)
 C07D 277/04(2006.01)
A61K 31/426(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; C07D 417/14; C07D 417/04; C07D 471/04; C07D 451/04
(86) International application number:
PCT/CN2024/103156
(87) International publication number:
WO 2025/007859 (09.01.2025 Gazette 2025/02)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 03.07.2023 WO PCT/CN2023/105592

(71) Applicant: Insilico Medicine IP Limited
Central, Hong Kong (HK)

(72) Inventors:
  • DING, Xiao
    Shanghai 201203 (CN)
  • LIU, Jinxin
    Shanghai 201203 (CN)
  • MENG, Fanye
    Shanghai 201203 (CN)
  • REN, Feng
    Shanghai 201203 (CN)
  • WANG, Yazhou
    Shanghai 201203 (CN)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)

   


(54) SUBSTITUTED THIAZOLE COMPOUNDS AS CDK2/4/6 INHIBITORS AND METHODS OF USE THEREOF