(19)
(11) EP 4 739 683 A1

(12)

(43) Date of publication:
13.05.2026 Bulletin 2026/20

(21) Application number: 23741602.9

(22) Date of filing: 05.07.2023
(51) International Patent Classification (IPC): 
C07D 471/04(2006.01)
C07D 401/12(2006.01)
A61P 35/00(2006.01)
A61K 31/47(2006.01)
C07D 217/04(2006.01)
C07D 401/14(2006.01)
A61K 31/4375(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 471/04; A61P 35/00; C07D 401/14; C07D 401/12; C07D 217/04
(86) International application number:
PCT/EP2023/068561
(87) International publication number:
WO 2025/008059 (09.01.2025 Gazette 2025/02)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(71) Applicant: Janssen Pharmaceutica NV
2340 Beerse (BE)

(72) Inventors:
  • STANSFIELD, Ian
    2340 Beerse (BE)
  • LEONARD, Kristi Anne
    Raritan, New Jersey 08869 (US)
  • WINTERS, Michael Peter
    Raritan, New Jersey 08869 (US)
  • BERTHELOT, Didier Jean Claude
    2340 Beerse (BE)

(74) Representative: Campabadal Monfa, Gemma 
Johnson & Johnson Patent Law Department Turnhoutseweg 30
2340 Beerse
2340 Beerse (BE)

   


(54) 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS