(19)
(11) EP 4 739 694 A2

(12)

(88) Date of publication A3:
30.05.2025

(43) Date of publication:
13.05.2026 Bulletin 2026/20

(21) Application number: 24836552.0

(22) Date of filing: 02.07.2024
(51) International Patent Classification (IPC): 
C07D 487/14(2006.01)
C07D 403/12(2006.01)
A61K 31/4025(2006.01)
A61P 35/00(2006.01)
C07D 487/18(2006.01)
A61K 31/4995(2006.01)
A61K 31/404(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 487/22; C07D 498/22
(86) International application number:
PCT/US2024/036607
(87) International publication number:
WO 2025/010294 (09.01.2025 Gazette 2025/02)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 03.07.2023 US 202363524781 P

(71) Applicant: Blossomhill Therapeutics, Inc.
San Diego, CA 92121 (US)

(72) Inventors:
  • CUI, Jingrong Jean
    San Diego, California 92121 (US)
  • RUI, Eugene Yuanjin
    San Diego, California 92121 (US)
  • ROGERS, Evan, W.
    San Diego, California 92121 (US)
  • ZHAI, Dayong
    San Diego, California 92121 (US)

(74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB 
Leopoldstraße 4
80802 München
80802 München (DE)

   


(54) MACROCYCLIC COMPOUNDS AND USE AS TYK2 INHIBITORS