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EP 4 739 699 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24838712.8 (22) Date of filing: 05.07.2024

(51) International Patent Classification (IPC):  C07K 14/005(2006.01) C12N 5/0783(2010.01) C12N 15/49(2006.01) A61K 35/17(2025.01) C07K 14/155(2006.01) C12N 15/86(2006.01) C12N 15/62(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 14/005; C12N 15/86; C12N 2740/16022; C12N 2740/16043; C07K 14/7051; C07K 2319/00; C12N 9/104; C07K 14/705; C07K 2319/03; A61K 40/31; C12N 2510/00; C12N 5/0636; A61K 40/11; A61K 40/30; A61K 40/4221 (86) International application number: PCT/CN2024/103850 (87) International publication number: WO 2025/011459 (16.01.2025 Gazette 2025/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 07.07.2023 WO PCT/CN2023/106325 (71) Applicants: Legend Biotech Ireland Limited Dublin 18, D18 T934 (IE) Legend Biotech USA Inc. Somerset, NJ 08873 (US)	(72) Inventors: ZHAO, Yuncheng Nanjing, Jiangsu 211100 (CN) HUANG, Xin Nanjing, Jiangsu 211100 (CN) WANG, Bing Nanjing, Jiangsu 211100 (CN) XU, Changmeng Nanjing, Jiangsu 211100 (CN) ZHUANG, Qiuchuan Nanjing, Jiangsu 211100 (CN) (74) Representative: Murgitroyd & Company  165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)