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EP 4 739 700 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24840339.6 (22) Date of filing: 05.07.2024

(51) International Patent Classification (IPC):  C07K 14/135(2006.01) A61K 39/12(2006.01) C12N 15/86(2006.01) A61K 38/16(2006.01) A61P 31/14(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/12; A61P 31/14; C07K 14/005; C12N 2760/18534; C12N 2760/18522; C12N 2760/18523; A61K 2039/54; A61K 2039/545; A61K 2039/70; A61K 38/00 (86) International application number: PCT/US2024/036932 (87) International publication number: WO 2025/014822 (16.01.2025 Gazette 2025/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 07.07.2023 US 202363525447 P (71) Applicants: Emory University Atlanta, Georgia 30322 (US) Children's Healthcare of Atlanta, Inc. Atlanta, GA 30329 (US)	(72) Inventors: ANDERSON, Larry James Atlanta, Georgia 30322 (US) HA, Binh Atlanta, Georgia 30322 (US) SUN, Heying Atlanta, Georgia 30322 (US) (74) Representative: Duncombe, Jessica et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)