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EP 4 739 702 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24838738.3 (22) Date of filing: 05.07.2024

(51) International Patent Classification (IPC):  C07K 14/725(2006.01) A61K 39/00(2006.01) G01N 33/574(2006.01) G01N 33/68(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 14/7051; C07K 2319/00; C07K 2319/03; A61K 40/32; A61K 40/11 (86) International application number: PCT/CN2024/103982 (87) International publication number: WO 2025/011485 (16.01.2025 Gazette 2025/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 07.07.2023 US 202363512299 P (71) Applicants: The University of Hong Kong Hong Kong (HK) Centre for Oncology and Immunology Limited Hong Kong (HK) University Health Network Toronto, Ontario M5G 2C4 (CA)

(72) Inventors: MAK, Tak Wah Hong Kong Science Park, Shatin, N.T. Hong Kong (CN) ZHENG, Chunxing Hong Kong Science Park, Shatin, N.T. Hong Kong (CN) (74) Representative: HGF  HGF Limited 4th Floor, 1 City Square Leeds LS1 2ES Leeds LS1 2ES (GB)