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EP 4 739 713 A1

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(43) Date of publication: 13.05.2026 Bulletin 2026/20 (21) Application number: 24836434.1 (22) Date of filing: 02.07.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12N 5/10(2006.01) A61K 35/17(2025.01) A61P 35/00(2006.01) C07K 14/725(2006.01) A61K 39/395(2006.01) G01N 33/577(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/30; C07K 2317/21; C07K 2317/55; C07K 2317/92; C07K 2317/33; C07K 2317/732; C07K 2317/52; C07K 2317/30; C07K 2317/31; C07K 16/2809; C07K 2317/622; A61K 47/68031; A61K 47/68035; A61K 47/6851; A61K 40/11; A61K 40/31; A61K 40/4202; A61K 2239/51; A61K 31/40; A61K 31/4745; A61K 31/5383; A61K 31/551; A61K 31/4045; A61K 31/437; G01N 33/5759   C-Sets: A61K 31/551, A61K 2300/00; A61K 31/4045, A61K 2300/00; A61K 31/40, A61K 2300/00; A61K 31/4745, A61K 2300/00; A61K 31/5383, A61K 2300/00; A61K 31/366, A61K 2300/00; (86) International application number: PCT/SG2024/050432 (87) International publication number: WO 2025/010028 (09.01.2025 Gazette 2025/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 05.07.2023 SG 10202301928R (71) Applicant: Agency for Science, Technology and Research Singapore 138632 (SG)	(72) Inventors: WANG, Cheng-I Singapore 138648 (SG) WANG, Bei Singapore 138648 (SG) NGOH, Zi Xian Eve Singapore 138648 (SG) MOHD SALLEH, Siti Nazihah Singapore 138648 (SG) YEAP, Yee Chin, Yvonne Singapore 138648 (SG) (74) Representative: Wilson Gunn  Centurion House 129 Deansgate Manchester M3 3WR Manchester M3 3WR (GB)