(19)
(11) EP 4 740 018 A1

(12)

(43) Date of publication:
13.05.2026 Bulletin 2026/20

(21) Application number: 24739191.5

(22) Date of filing: 02.07.2024
(51) International Patent Classification (IPC): 
G01N 33/68(2006.01)
(52) Cooperative Patent Classification (CPC):
G01N 33/6893; G01N 2333/4742; G01N 2333/78; G01N 2800/085; G01N 2800/50
(86) International application number:
PCT/EP2024/068619
(87) International publication number:
WO 2025/008357 (09.01.2025 Gazette 2025/02)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 03.07.2023 EP 23306119

(71) Applicants:
  • Institut National de la Santé et de la Recherche Médicale
    75013 Paris (FR)
  • Assistance Publique-Hôpitaux de Paris (APHP)
    75012 Paris (FR)
  • Université Paris Cité
    75006 Paris (FR)

(72) Inventor:
  • RAUTOU, Pierre-Emmanuel
    75870 Paris cedex 18 (FR)

(74) Representative: Inserm Transfert 
PariSanté Campus 10 rue d'Oradour-sur-Glane
75015 Paris
75015 Paris (FR)

   


(54) LARGE EXTRACELLULAR VESICLES AS BIOMARKERS FOR PREDICTING ORGAN FAILURES AND SURVIVAL TIME OF PATIENTS SUFFERING FROM AN ACUTE DECOMPENSATION OF CIRRHOSIS