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(11)

EP 4 770 512 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860995.0 (22) Date of filing: 29.08.2024

(51) International Patent Classification (IPC):  A61B 5/021(2006.01) G16H 50/20(2018.01) A61B 5/11(2006.01) (52) Cooperative Patent Classification (CPC): G16H 50/20; G16H 30/20; G16H 30/40; G16H 50/30; G16H 40/67; G16H 50/70; A61B 5/0077; A61B 5/02125; A61B 5/1128; A61B 5/7267 (86) International application number: PCT/US2024/044332 (87) International publication number: WO 2025/049680 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.08.2023 US 202363579332 P (71) Applicant: MUSC Foundation for Research Development Charleston, SC 29425 (US)	(72) Inventors: ESPOSITO, Michele Charleston, SC 29425 (US) WEHBE, Ramsey Charleston, SC 29425 (US) (74) Representative: Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB  Ganghoferstraße 68 B 80339 München 80339 München (DE)