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EP 4 770 625 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24861245.9 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  A61K 31/025(2006.01) A61K 31/18(2006.01) A61K 31/03(2006.01) A61K 31/145(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/18; A61K 45/06; A61K 33/243; A61P 25/00   C-Sets: A61K 33/243, A61K 2300/00; A61K 31/18, A61K 2300/00; (86) International application number: PCT/US2024/044897 (87) International publication number: WO 2025/050066 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 US 202363580217 P (71) Applicants: Board of Regents, The University of Texas System Austin, TX 78701 (US) The Scripps Research Institute La Jolla, CA 92037 (US)

(72) Inventors: SHIM, Hong Seok Austin, Texas 78701 (US) DEPINHO, Ronald A. Austin, Texas 78701 (US) BOUTIN, Adam T. Austin, Texas 78701 (US) SCHULTZ, Peter G. La Jolla, California 92037 (US) LAIRSON, Luke L. La Jolla, California 92037 (US) BOLLONG, Michael J. La Jolla, California 92037 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)