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(11)

EP 4 770 628 A2

(12)

(88) Date of publication A3: 24.04.2025 (43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860902.6 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/397(2006.01) A61K 31/44(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; C07D 403/14; C07D 471/14; C07D 519/00; C07D 405/14; A61P 35/00 (86) International application number: PCT/US2024/044106 (87) International publication number: WO 2025/049521 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.08.2023 US 202363579241 P 12.01.2024 US 202463620520 P 24.05.2024 US 202463651602 P (71) Applicant: Syndax Pharmaceuticals, Inc. New York, NY 10017 (US)

(72) Inventors: MCGEEHAN, Gerard, M. Newtown Square, Pennsylvania 19073 (US) MILLER, William, H. Collegeville, Pennsylvania 19426 (US) SAMANTA, Swapan Kumar Hyderabad, 500076 (IN) REDDY, Virsinha Venkat Hyderabad, 500010 (IN) KUMAR, Singam Naveen Hyderabad, 500083 (IN) KULKARNI, Santosh S. Bangalore 560078 (IN) (74) Representative: Haseltine Lake Kempner LLP  Cheapside House 138 Cheapside London EC2V 6BJ London EC2V 6BJ (GB)