(19)

(11)

EP 4 770 630 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860946.3 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/16(2006.01) A61K 31/4045(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04 (86) International application number: PCT/US2024/044223 (87) International publication number: WO 2025/049604 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.08.2023 US 202363535282 P 01.04.2024 US 202463572752 P (71) Applicant: Maze Therapeutics, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: PITZEN, Jennifer South San Francisco, CA 94080 (US) ZIEBENHAUS, Chris South San Francisco, CA 94080 (US) MELLEM, Kevin South San Francisco, CA 94080 (US) COOPER, Nicole South San Francisco, CA 94080 (US) REID, Adam Neil South San Francisco, CA 94080 (US) SCHAMMEL, Alexander Wayne South San Francisco, CA 94080 (US) KARMEL, Caleb Henry South San Francisco, CA 94080 (US) SINZ, Christopher Joseph South San Francisco, CA 94080 (US) LEE, Patrick Sang Tae South San Francisco, CA 94080 (US) WAHLERS, Jessica South San Francisco, CA 94080 (US) FASTMAN, Nathan South San Francisco, CA 94080 (US) TZITZILONIS, Christos South San Francisco, CA 94080 (US) MORGANS, David, John, Jr. South San Francisco, CA 94080 (US) LIU, Yuxi South San Francisco, CA 94080 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)