(19)

(11)

EP 4 770 631 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860961.2 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/505(2006.01) A61K 31/16(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): C07D 487/04; C07D 519/00; C07D 473/34; C07D 239/42 (86) International application number: PCT/US2024/044257 (87) International publication number: WO 2025/049624 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.08.2023 US 202363535246 P (71) Applicant: Purdue Research Foundation West Lafayette, IN 47906 (US)	(72) Inventors: HUANG, Rong Lafayette, Indiana 47906 (US) IYAMU, Iredia David Lawrence, Kansas 66049 (US) (74) Representative: Secerna LLP  The Old Fire Station 18 Clifford Street York YO1 9RD York YO1 9RD (GB)