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EP 4 770 632 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860975.2 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/13(2006.01) A61K 31/404(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/4709; C07D 401/06; C07D 209/08; C07D 401/12 (86) International application number: PCT/US2024/044288 (87) International publication number: WO 2025/049644 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.08.2023 US 202363535235 P (71) Applicants: United States Government as Represented by The Department of Veterans Affairs Washington, DC 20420 (US) Emory University Atlanta, GA 30322 (US) Georgia Tech Research Corporation Atlanta, GA 30332-0415 (US)

(72) Inventors: HECKER, Louise Atlanta, GA 30309 (US) OYELERE, Adegboyega Marietta, GA 30068 (US) WU, Bocheng Medford, MA 02155 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)