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EP 4 770 646 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24762306.9 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  A61K 31/5377(2006.01) A61P 35/00(2006.01) A61K 45/06(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/5377; A61K 45/06; A61P 35/00 (86) International application number: PCT/EP2024/073974 (87) International publication number: WO 2025/045901 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 31.08.2023 EP 23194748 29.09.2023 EP 23200990 (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)

(72) Inventors: ARCHER, Venice Rosalie Garden City Hertfordshire AL7 1TW (GB) BORDOGNA, Walter 4070 Basel (CH) CARDONA GAVALDON, Andres 4070 Basel (CH) GOLDING, Sophie Maude Alice 4070 Basel (CH) MAUDIRE ÉPOUSE HILTON, Magalie 4070 Basel (CH) NOÉ, Johannes Alexander 4070 Basel (CH) OCHI LOHMANN, Tania Helena 4070 Basel (CH) RUF, Thorsten 4070 Basel (CH) XU, Tingting Shanghai 201203 (CN) ZEAITER, Ali 4070 Basel (CH) (74) Representative: D Young & Co LLP  3 Noble Street London EC2V 7BQ London EC2V 7BQ (GB)