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(11)

EP 4 770 648 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24808799.1 (22) Date of filing: 31.10.2024

(51) International Patent Classification (IPC):  A61K 31/675(2006.01) A61P 1/00(2006.01) A61K 45/06(2006.01) A61P 11/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/675; A61P 11/00; A61P 1/00; A61K 45/06 (86) International application number: PCT/US2024/053848 (87) International publication number: WO 2025/096754 (08.05.2025 Gazette 2025/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 31.10.2023 US 202363594746 P (71) Applicant: MUSC Foundation for Research Development Charleston, SC 29425 (US)	(72) Inventors: FEGHALI-BOSTWICK, Carol Mt. Pleasant, SC 20466 (US) SHARMA, Shailza Charleston, SC 29414 (US) (74) Representative: Forresters IP LLP  Skygarden Erika-Mann-Straße 11 80636 München 80636 München (DE)