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(11)

EP 4 770 649 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860903.4 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  A61K 31/7105(2006.01) A61P 25/28(2006.01) A61P 11/00(2006.01) A61P 9/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 9/00; A61P 11/00; A61P 25/28; C12N 15/113; C12N 2310/14 (86) International application number: PCT/US2024/044115 (87) International publication number: WO 2025/049527 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.08.2023 US 202363579371 P (71) Applicant: The Medical College of Wisconsin, Inc. Milwaukee, WI 53226 (US)	(72) Inventors: MAMMOTO, Akiko Pewaukee, Wisconsin 53072 (US) MAMMOTO, Tadanori Pewaukee, Wisconsin 53072 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)