(19)
(11) EP 4 770 650 A2

(12)

(88) Date of publication A3:
17.04.2025

(43) Date of publication:
08.07.2026 Bulletin 2026/28

(21) Application number: 24863776.1

(22) Date of filing: 09.09.2024
(51) International Patent Classification (IPC): 
A61K 31/7125(2006.01)
A61P 3/00(2006.01)
C07H 21/00(2006.01)
 A61K 31/713(2006.01)
A61P 9/12(2006.01)
C12N 15/113(2010.01)
(52) Cooperative Patent Classification (CPC):
C12N 2310/351; C12N 15/113; C12N 2310/321; C12N 2310/322; A61K 31/713
 
C-Sets:
  1. C12N 2310/321, C12N 2310/3521;
  2. C12N 2310/322, C12N 2310/3533;
(86) International application number:
PCT/US2024/045826
(87) International publication number:
WO 2025/054596 (13.03.2025 Gazette 2025/11)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 08.09.2023 US 202363581620 P
28.09.2023 US 202363586079 P

(71) Applicant: Wave Life Sciences Ltd.
Singapore 018936 (SG)

(72) Inventors:
  • LIU, Wei
    Cambridge, MA 02138 (US)
  • YANG, Hsiu-Chiung
    Cambridge, MA 02138 (US)
  • VARGEESE, Chandra
    Cambridge, MA 02138 (US)
  • IWAMOTO, Naoki
    Cambridge, MA 02138 (US)
  • LUU, Khoa, Ngoc Dang
    Cambridge, MA 02138 (US)
  • SHAH, Himali, Kavin
    Cambridge, MA 02138 (US)
  • MARAPPAN, Subramanian
    Cambridge, MA 02138 (US)
  • KAWAMOTO, Tomomi
    Cambridge, MA 02138 (US)
  • LAMATTINA, Anthony
    Cambridge, MA 02138 (US)
  • SHIVA PRAKASHA, Priyanka
    Cambridge, MA 02138 (US)

(74) Representative: Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB 
Ganghoferstraße 68 B
80339 München
80339 München (DE)

   


(54) INHIBIN SUBUNIT BETA E-RELATED DOUBLE STRANDED OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO