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EP 4 770 652 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860967.9 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  A61K 35/17(2025.01) C12N 5/0783(2010.01) A61P 37/06(2006.01) C12N 5/10(2006.01) (52) Cooperative Patent Classification (CPC): A61P 37/06; A61K 40/4211; C12N 5/0636; C12N 2510/00; A61K 40/31; C12N 2310/20; C12N 15/1138; A61K 40/11; A61K 40/50; A61K 2239/48   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/315, C12N 2310/344; (86) International application number: PCT/US2024/044268 (87) International publication number: WO 2025/049631 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.08.2023 US 202363579076 P 12.01.2024 US 202463620643 P 09.05.2024 US 202463645074 P (71) Applicant: Kyverna Therapeutics, Inc. Emeryville, California 94608 (US)

(72) Inventors: CHENG, Joseph K. Emeryville, California 94608 (US) FLANDEZ, Jeanne Emeryville, California 94608 (US) KWONG, Brandon Emeryville, California 94608 (US) LEVINSON, Sarah Asheville, North Carolina 28804 (US) MAHNE, Ashley E. Emeryville, California 94608 (US) VAN BLARCOM, Tom Emeryville, California 94608 (US) (74) Representative: Elkington and Fife LLP  Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)