(19)

(11)

EP 4 770 659 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24861262.4 (22) Date of filing: 01.09.2024

(51) International Patent Classification (IPC):  A61K 38/17(2006.01) C07K 19/00(2006.01) A61P 9/06(2006.01) C07K 14/05(2006.01) (52) Cooperative Patent Classification (CPC): A61P 9/06; C07K 14/723; A61K 38/00; C07K 2319/10 (86) International application number: PCT/US2024/044936 (87) International publication number: WO 2025/050091 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 US 202363580099 P (71) Applicant: Ohio State Innovation Foundation Columbus OH 43210 (US)	(72) Inventors: EL REFAEY, Mona Columbus, Ohio 43210 (US) MALHOTRA, Nipun Columbus, Ohio 43210 (US) (74) Representative: Berggren Oy  P.O. Box 16 Fabianinkatu 21 00101 Helsinki 00101 Helsinki (FI)