(19)
(11) EP 4 770 664 A1

(12)

(43) Date of publication:
08.07.2026 Bulletin 2026/28

(21) Application number: 24861020.6

(22) Date of filing: 29.08.2024
(51) International Patent Classification (IPC): 
A61K 38/48(2006.01)
A61P 11/00(2006.01)
C12N 9/68(2006.01)
 A61K 38/49(2006.01)
A61P 9/00(2006.01)
A61K 31/145(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 38/49; A61P 9/00; A61P 11/00; C12N 9/6435; A61K 45/06; A61K 38/55; A61K 38/484; A61K 31/222; A61K 31/444
 
C-Sets:
  1. A61K 31/222, A61K 2300/00;
  2. A61K 31/444, A61K 2300/00;
  3. A61K 38/49, A61K 2300/00;
  4. A61K 38/55, A61K 2300/00;
  5. A61K 38/484, A61K 2300/00;
(86) International application number:
PCT/US2024/044400
(87) International publication number:
WO 2025/049724 (06.03.2025 Gazette 2025/10)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 29.08.2023 US 202363535132 P

(71) Applicants:
  • Board of Regents of the University of Nebraska
    Lincoln, NE 68583-0745 (US)
  • Massachusetts Institute of Technology
    Cambridge, MA 02139-4301 (US)

(72) Inventors:
  • BARRETT, Christopher, D.
    Bennington, NE 68007 (US)
  • YAFFE, Michael, B.
    Cambridge, MA 02139 (US)

(74) Representative: Potter Clarkson 
Chapel Quarter Mount Street
Nottingham NG1 6HQ
Nottingham NG1 6HQ (GB)

   


(54) COMPOSITIONS AND METHODS FOR TREATING PLEURAL SPACE INFECTIONS AND HEMOTHORAX