(19)
(11) EP 4 770 666 A2

(12)

(88) Date of publication A3:
24.04.2025

(43) Date of publication:
08.07.2026 Bulletin 2026/28

(21) Application number: 24782670.4

(22) Date of filing: 30.08.2024
(51) International Patent Classification (IPC): 
A61K 39/00(2006.01)
G16B 20/00(2019.01)
 C07K 14/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 39/0011; G16B 30/00; G16B 40/00; C07K 14/4748
(86) International application number:
PCT/US2024/044819
(87) International publication number:
WO 2025/050009 (06.03.2025 Gazette 2025/10)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 01.09.2023 US 202363580300 P

(71) Applicant: Children's Hospital Medical Center
Cincinnati, Ohio 45229 (US)

(72) Inventors:
  • SALOMONIS, Nathan
    Cincinnati, Ohio 45229 (US)
  • LI, Guangyuan
    Cincinnati, Ohio 45229 (US)

(74) Representative: Potter Clarkson 
Chapel Quarter Mount Street
Nottingham NG1 6HQ
Nottingham NG1 6HQ (GB)

   


(54) IDENTIFICATION OF TARGETS FOR IMMUNOTHERAPY IN MELANOMA USING SPLICING-DERIVED NEOANTIGENS