(19)

(11)

EP 4 770 670 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860904.2 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61P 35/04(2006.01) C07K 19/00(2006.01) C07K 14/55(2006.01) A61K 9/08(2006.01) A61K 38/20(2006.01) C07K 14/54(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/395; A61P 35/04; C07K 14/55; C07K 14/5434; C07K 2319/00; A61K 45/06; A61K 38/2013; A61K 38/208; A61K 38/385; A61K 38/177; C07K 14/765; C07K 14/70503; C07K 2317/76; C07K 16/2818; A61K 2039/505; A61K 2039/545; C07K 2319/70   C-Sets: A61K 39/395, A61K 2300/00; A61K 38/208, A61K 2300/00; A61K 38/2013, A61K 2300/00; A61K 38/385, A61K 2300/00; A61K 38/177, A61K 2300/00; (86) International application number: PCT/US2024/044117 (87) International publication number: WO 2025/049528 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.08.2023 US 202363579429 P 27.10.2023 US 202363593615 P (71) Applicant: Cullinan Amber Corp. Cambridge, MA 02142 (US)

(72) Inventors: MEHTA, Naveen K. Cambridge, Massachusetts 02142 (US) RAKHRA, Kavya Cambridge, Massachusetts 02142 (US) MEETZE, Kristian Cambridge, Massachusetts 02142 (US) BAEUERLE, Patrick A. Cambridge, Massachusetts 02142 (US) MICHAELSON, Jennifer S. Cambridge, Massachusetts 02142 (US) LIU, Xiaohong Cambridge, Massachusetts 02142 (US) LI, Shengting Cambridge, Massachusetts 02142 (US) (74) Representative: Studio Torta S.p.A.  Via Viotti, 9 10121 Torino 10121 Torino (IT)