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(11)

EP 4 770 673 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24776075.4 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  A61K 41/00(2020.01) A61K 51/04(2006.01) A61N 5/10(2006.01) A61K 47/54(2017.01) A61P 35/00(2006.01) A61K 103/30(2006.01) (52) Cooperative Patent Classification (CPC): A61K 41/0038; A61K 47/542; A61K 47/54; A61K 51/0402; A61P 35/00; A61K 51/0497 (86) International application number: PCT/US2024/044778 (87) International publication number: WO 2025/049985 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 31.08.2023 US 202363535767 P 04.03.2024 US 202463560987 P (71) Applicant: Purdue Research Foundation West Lafayette, IN 47906 (US)	(72) Inventors: LOW, Philip Stewart Lafayette, Indiana 47906 (US) SRINIVASARAO, Madduri Lafayette, Indiana 47906 (US) SENGUPTA, Sagnik Lafayette, Indiana 47906 (US) (74) Representative: Secerna LLP  The Old Fire Station 18 Clifford Street York YO1 9RD York YO1 9RD (GB)