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EP 4 770 679 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24861154.3 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) G01N 33/574(2006.01) A61K 39/395(2006.01) A61P 35/00(2006.01) G01N 33/577(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/30; C07K 16/32; G01N 2800/52; G01N 2333/70596; A61K 47/6851; A61K 47/6855; A61K 47/68037; G01N 33/57515 (86) International application number: PCT/US2024/044699 (87) International publication number: WO 2025/049926 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 31.08.2023 US 202363535619 P (71) Applicant: Yale University New Haven, CT 06510 (US)	(72) Inventors: RIMM, David New Haven, Connecticut 06511 (US) ROBBINS, Charles New Haven, Connecticut 06511 (US) HE, Mengni New Haven, Connecticut 06511 (US) NWE NYEIN CHAN, Nay New Haven, Connecticut 06511 (US) (74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB  Leopoldstraße 4 80802 München 80802 München (DE)