(19)
(11) EP 4 770 994 A1

(12)

(43) Date of publication:
08.07.2026 Bulletin 2026/28

(21) Application number: 24772537.7

(22) Date of filing: 30.08.2024
(51) International Patent Classification (IPC): 
C07D 209/34(2006.01)
A61P 1/16(2006.01)
 A61K 31/404(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 1/16; C07B 2200/13; C07D 209/34
(86) International application number:
PCT/US2024/044713
(87) International publication number:
WO 2025/049936 (06.03.2025 Gazette 2025/10)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 31.08.2023 IN 202341058423

(71) Applicant: BioMarin Pharmaceutical Inc.
Novato, CA 94949 (US)

(72) Inventors:
  • DUNBAR, Ruth
    Craigavon BT63 5QD (GB)
  • GALBRAITH, Jana
    Craigavon BT63 5QD (GB)
  • BURKE, Sarah
    Craigavon BT63 5QD (GB)
  • MOODY, James
    Craigavon BT63 5QD (GB)
  • REDDY, K Rama Subba
    Hyderabad, 500032 (IN)
  • SIHORKAR, Vaibhav
    Hyderabad, 500032 (IN)
  • MAHAMMAD, Shahe
    Hyderabad, 500032 (IN)
  • PEDDURI, Kiran
    Hyderabad, 500032 (IN)

(74) Representative: Jones Day 
Gewürzmühlstr. 11
80538 München
80538 München (DE)

   


(54) SOLID FORMS OF N-1-(2-CHLORO-3-FLUOROPHENYL)-1-HYDROXYPENTAN-2-YL)-7-FLUORO-2-OXOINDOLINE-4-CARBOXAMIDE AND METHODS OF THEIR PREPARATION