(19)

(11)

EP 4 770 995 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24776068.9 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C07D 209/34(2006.01) A61K 31/404(2006.01) A61P 1/16(2006.01) (52) Cooperative Patent Classification (CPC): C07D 209/34; A61P 1/16 (86) International application number: PCT/US2024/044680 (87) International publication number: WO 2025/049912 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 31.08.2023 US 202363535850 P (71) Applicant: BioMarin Pharmaceutical Inc. Novato, CA 94949 (US)	(72) Inventors: BOURBON, Pauline Novato, CA 94949 (US) CAMPBELL, Colm Novato, CA 94949 (US) O'BRIEN, Claire Novato, CA 94949 (US) WENZEL, Heather, Ann Novato, CA 94949 (US) PADEN, Warren Craigavon BT63 5QD (GB) ROBERTSON, Gerard, Phillip Craigavon BT63 5QD (GB) BOWEN, John George Novato, CA 94949 (US) (74) Representative: Jones Day  Gewürzmühlstr. 11 80538 München 80538 München (DE)