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(11)

EP 4 770 996 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24772493.3 (22) Date of filing: 27.08.2024

(51) International Patent Classification (IPC):  C07D 213/74(2006.01) C07D 403/14(2006.01) C07D 413/14(2006.01) A61K 31/4427(2006.01) C07D 401/12(2006.01) C07D 405/14(2006.01) A61P 25/28(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/12; C07D 403/14; C07D 213/74; C07D 413/14; C07D 405/14; A61P 25/28 (86) International application number: PCT/US2024/044067 (87) International publication number: WO 2025/049495 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.08.2023 US 202363579221 P (71) Applicants: Genentech Inc. South San Francisco, California 94080-4990 (US) Convelo Therapeutics, Inc. Cleveland, OH 44106 (US)

(72) Inventors: BRAUN, Marie-Gabrielle San Francisco, California 94080-4990 (US) CASTANEDO, Georgette Marie San Francisco, California 94080-4990 (US) DOREL, Ruth San Francisco, California 94080-4990 (US) LIANG, Jun San Francisco, California 94080-4990 (US) UNG, Man Un San Francisco, California 94080-4990 (US) CARRUTHERS, Nicholas Cleveland, Ohio 44106 (US) FACTOR, Daniel Cleveland, Ohio 44106 (US) ADAMS, Drew Cleveland, Ohio 44106 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)