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EP 4 771 001 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24786348.3 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C07D 401/14(2006.01) C07D 405/14(2006.01) A61K 31/4245(2006.01) A61K 31/4709(2006.01) A61K 31/497(2006.01) A61P 9/10(2006.01) A61P 13/12(2006.01) C07D 403/14(2006.01) C07D 413/14(2006.01) A61K 31/4439(2006.01) A61K 31/4965(2006.01) A61P 3/10(2006.01) A61P 11/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 413/14; C07D 403/14; C07D 405/14; C07D 401/14; A61P 3/10; A61P 13/12; A61P 11/00; A61P 9/10; A61K 45/06 (86) International application number: PCT/CN2024/115894 (87) International publication number: WO 2025/045208 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 31.08.2023 WO PCT/CN2023/116141 (71) Applicant: Gasherbrum Bio, Inc. South San Francisco, CA 94080 (US)	(72) Inventors: HUANG, Wei Shanghai 200003 (CN) LEI, Hui Shanghai 200003 (CN) LU, Chunliang Shanghai 200003 (CN) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)