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EP 4 771 003 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24782664.7 (22) Date of filing: 27.08.2024

(51) International Patent Classification (IPC):  C07D 405/08(2006.01) C07D 405/14(2006.01) A61P 25/00(2006.01) C07D 405/12(2006.01) A61K 31/415(2006.01) (52) Cooperative Patent Classification (CPC): C07D 405/08; C07D 405/12; C07D 405/14; A61P 25/00 (86) International application number: PCT/US2024/043947 (87) International publication number: WO 2025/049419 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.08.2023 US 202363579111 P (71) Applicant: GENZYME CORPORATION Cambridge, Massachusetts 02141 (US)	(72) Inventors: JIANG, John Ziqi Cambridge, Massachusetts 02141 (US) LIM, Sungtaek Cambridge, Massachusetts 02141 (US) MERRIMAN, Gregory H. Cambridge, Massachusetts 02141 (US) MUELLER, Paul Justin Cambridge, Massachusetts 02141 (US) THURAIRATNAM, Sukanthini Cambridge, Massachusetts 02141 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)