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EP 4 771 004 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860973.7 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  C07D 413/14(2006.01) A61K 45/06(2006.01) A61P 35/00(2006.01) A61K 31/4045(2006.01) A61P 11/00(2006.01) C07D 405/14(2006.01) (52) Cooperative Patent Classification (CPC): A61K 45/06; A61P 11/00; A61P 35/00; C07D 405/14; C07D 413/14; A61K 47/545; G01N 33/56983; G01N 2800/12 (86) International application number: PCT/US2024/044283 (87) International publication number: WO 2025/049640 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.08.2023 US 202363535218 P (71) Applicants: The United States Government As Represented By The Department Of Veterans Affairs Washington, DC 20420 (US) Emory University Atlanta, GA 30322 (US) Georgia Tech Research Corporation Atlanta, GA 30332-0415 (US)

(72) Inventors: WALUNJ, Dipak Atlanta, GA 30318 (US) HECKER, Louise Atlanta, GA 30309 (US) OYELERE, Adegboyega Marietta, GA 30068 (US) WU, Bocheng Medford, MA 02155 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)