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EP 4 771 009 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24857563.1 (22) Date of filing: 29.08.2024

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61P 25/02(2006.01) C07D 475/00(2006.01) A61K 31/519(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 475/00; A61P 25/02; A61P 35/00; C07D 471/04; A61K 45/06 (86) International application number: PCT/CA2024/051124 (87) International publication number: WO 2025/043349 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.08.2023 US 202363535418 P (71) Applicants: Ontario Institute for Cancer Research (OICR) Toronto, ON M5G 0A3 (CA) University Health Network Toronto, Ontario M5G 2C4 (CA)

(72) Inventors: AL-AWAR, Rima Toronto, Ontario M5S 2X8 (CA) ISAAC, Methvin Brampton, Ontario L6P 2C1 (CA) LAUFER, Radek Oakville, Ontario L6M 4C8 (CA) UEHLING, David Toronto, Ontario M5M 4N3 (CA) ROTTAPEL, Robert Kenneth Toronto, Ontario M5M 3L9 (CA) (74) Representative: HGF  HGF Limited 4th Floor, 1 City Square Leeds LS1 2ES Leeds LS1 2ES (GB)