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EP 4 771 010 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24861172.5 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61P 35/00(2006.01) A61K 31/4353(2006.01) A61P 37/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 37/00; A61P 35/00; C07D 471/04; C07D 498/06; C07D 519/00; A61K 31/506; A61K 45/06 (86) International application number: PCT/US2024/044751 (87) International publication number: WO 2025/049964 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 US 202363580215 P 06.12.2023 US 202363607012 P 23.01.2024 US 202463624171 P 28.06.2024 US 202463665670 P (71) Applicant: Treeline Biosciences, Inc. Watertown, Massachusetts 02472 (US)

(72) Inventors: OBERG, Kevin M. SAN DIEGO, California 92121 (US) HANSEN, Joshua D. SAN DIEGO, California 92121 (US) CORREA, Matthew D. SAN DIEGO, California 92121 (US) MARRONE, Tami J. SAN DIEGO, California 92121 (US) MCNEILL, Matthew H. SAN DIEGO, California 92121 (US) NAGY, Mark A. SAN DIEGO, California 92121 (US) SCHLEICHER, Kristin D. SAN DIEGO, California 92121 (US) VALIERE, Andrew SAN DIEGO, California 92121 (US) (74) Representative: D Young & Co LLP  3 Noble Street London EC2V 7BQ London EC2V 7BQ (GB)