(19)

(11)

EP 4 771 033 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24765423.9 (22) Date of filing: 02.09.2024

(51) International Patent Classification (IPC):  C07K 7/64(2006.01) C12N 15/10(2006.01) C40B 40/10(2006.01) A61K 38/12(2006.01) C07K 7/50(2006.01) C07K 14/705(2006.01) C40B 30/04(2006.01) G01N 33/68(2006.01) A61K 47/64(2017.01) C07K 19/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/1037; C40B 40/10; C07K 14/70582; C40B 30/04; G01N 33/6845; C07K 2319/60   C-Sets: C12N 15/1037, C12Q 2563/107; (86) International application number: PCT/EP2024/074501 (87) International publication number: WO 2025/046146 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 GB 202313403 (71) Applicant: BicycleTx Limited Cambridge CB21 6GS (GB)

(72) Inventors: PERKINS, Joseph Great Abington, Cambridge CB21 6GS (GB) MAGUIRE, Harry Great Abington, Cambridge CB21 6GS (GB) JACKSON, Matthew Great Abington, Cambridge CB21 6GS (GB) CHEN, Liuhong Great Abington, Cambridge CB21 6GS (GB) DEMYDCHUK, Yuliya Great Abington, Cambridge CB21 6GS (GB) PATEL, Jaimin Great Abington, Cambridge CB21 6GS (GB) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)