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EP 4 771 050 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24773222.5 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 31/18(2006.01) A61P 37/06(2006.01) A61K 39/395(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/28; C07K 16/2866; C07K 2317/34; C07K 2317/76; A61K 2039/505; C07K 2317/33; A61P 31/18; A61P 35/00; A61P 37/06 (86) International application number: PCT/US2024/044209 (87) International publication number: WO 2025/049591 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.08.2023 US 202363534939 P (71) Applicant: Regeneron Pharmaceuticals, Inc. Tarrytown, NY 10591 (US)

(72) Inventors: EDELMANN, Kurt Hans-Erwin Otto Tarrytown, New York 10591 (US) FRANKLIN, Matthew C. Tarrytown, New York 10591 (US) HACKETT, Caroline Gray New York, New York 10027 (US) HO, Jo-Hao Tarrytown, New York 10591 (US) KIM, Jee Hae Tarrytown, New York 10591 (US) MCGOLDRICK, Luke Lawrence Reedy Tarrytown, New York 10591 (US) MOORE, Michael John Tarrytown, New York 10591 (US) PANEA-RISTEA, Casandra Maria Tarrytown, New York 10591 (US) SAOTOME, Kei Tarrytown, New York 10591 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)