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EP 4 771 051 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24777115.7 (22) Date of filing: 10.09.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 39/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2875; A61K 2039/505; C07K 2317/92; C07K 2317/33; C07K 2317/565 (86) International application number: PCT/US2024/045966 (87) International publication number: WO 2025/059023 (20.03.2025 Gazette 2025/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 12.09.2023 US 202363537933 P (71) Applicant: AMGEN, INC. Thousand Oaks, CA 91320-1799 (US)

(72) Inventors: VANDER LUGT, Bryan Thousand Oaks, California 91320-1799 (US) HASEGAWA, Haruki Thousand Oaks, California 91320-1799 (US) ESTES, Bram Thousand Oaks, California 91320-1799 (US) SORIANO, Brian D. Thousand Oaks, California 91320-1799 (US) THOMSON, Christy Ann Thousand Oaks, 91320- 1799 (US) (74) Representative: Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB  Ganghoferstraße 68 B 80339 München 80339 München (DE)