(19)

(11)

EP 4 771 055 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24861129.5 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C07K 14/54(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): C07K 2317/35; C07K 2317/31; C07K 2317/60; C07K 16/2803; C07K 2317/94; C07K 2319/00; C07K 14/5428; C07K 14/47 (86) International application number: PCT/US2024/044639 (87) International publication number: WO 2025/049885 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 US 202363580203 P (71) Applicant: The Regents of the University of Michigan Ann Arbor, Michigan 48109-1280 (US)

(72) Inventors: BOND, Layne G. Ann Arbor, Michigan 48109 (US) KHALASAWI, Namir Ann Arbor, Michigan 48109 (US) KUO, Yun-Huai Wade Ann Arbor, Michigan 48109 (US) THURBER, Greg M. Ann Arbor, Michigan 48109 (US) GREINEDER, Colin F. Ann Arbor, Michigan 48109 (US) TESSIER, Peter M. Ann Arbor, Michigan 48109 (US) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)