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EP 4 771 058 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24861193.1 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C07K 16/30(2006.01) A61P 35/00(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/28; A61K 40/11; A61K 40/31; A61K 40/4202; G01N 2333/705; A61K 40/4211; A61K 2239/49; C12Q 1/6886; C12Q 2600/158; G01N 33/5759 (86) International application number: PCT/US2024/044799 (87) International publication number: WO 2025/049995 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 US 202363536341 P (71) Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Bethesda, MD 20817 (US)	(72) Inventor: UPADHYAY, Geeta Bethesda, Maryland 20817 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)