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EP 4 771 129 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860990.1 (22) Date of filing: 29.08.2024

(51) International Patent Classification (IPC):  C12N 5/071(2010.01) A61K 31/205(2006.01) G01N 33/68(2006.01) A61K 31/765(2006.01) C12Q 1/6804(2018.01) C12N 15/11(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/6863; G01N 2800/20; G01N 33/54388; G01N 2333/37; G01N 33/57505 (86) International application number: PCT/US2024/044324 (87) International publication number: WO 2025/049674 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.08.2023 US 202363579364 P 31.10.2023 US 202363594532 P (71) Applicant: Yale University New Haven CT 06510 (US)	(72) Inventors: DAMSKY, William New Haven, Connecticut 06511 (US) COHEN, Jeffrey New Haven, Connecticut 06511 (US) MURPHY, Michael New Haven, Connecticut 06511 (US) (74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB  Leopoldstraße 4 80802 München 80802 München (DE)