(19)
(11) EP 4 771 130 A1

(12)

(43) Date of publication:
08.07.2026 Bulletin 2026/28

(21) Application number: 24861291.3

(22) Date of filing: 03.09.2024
(51) International Patent Classification (IPC): 
C12N 5/0783(2010.01)
C12M 3/00(2006.01)
 G01N 15/149(2024.01)
B01F 25/00(2022.01)
(52) Cooperative Patent Classification (CPC):
C12N 5/0646; C12N 5/0012; C12N 2502/30; C12N 2502/1164; G01N 15/1492; G01N 15/1459; G01N 2015/1006; G01N 15/01; G01N 15/1427; C12M 23/16; C12M 25/01
(86) International application number:
PCT/US2024/045065
(87) International publication number:
WO 2025/050133 (06.03.2025 Gazette 2025/10)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 01.09.2023 US 202363536327 P

(71) Applicant: Northeastern University
Boston, MA 02115 (US)

(72) Inventors:
  • KONRY, Tania
    Boston, MA 02114 (US)
  • ESTEVAM, Jose
    Hopkinton, MA 01748 (US)
  • WHITE, Rachel
    Boston, MA 02130 (US)

(74) Representative: V.O. 
P.O. Box 87930
2508 DH Den Haag
2508 DH Den Haag (NL)

   


(54) ISOLATION AND EXPANSION OF NATURAL KILLER CELLS USING FLUORESCENCE-ACTIVATED DROPLET SORTING