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EP 4 771 138 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24772864.5 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C12N 9/12(2006.01) C12N 15/10(2006.01) C12N 9/22(2006.01) C12N 15/11(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C12N 15/102; C12N 2310/20; C12N 15/113; C12N 9/1276; C07K 2319/00; C07K 2319/80 (86) International application number: PCT/US2024/044701 (87) International publication number: WO 2025/049928 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 US 202363580168 P 01.09.2023 US 202363580188 P 15.02.2024 US 202463553974 P 25.04.2024 US 202463638559 P (71) Applicant: Arbor Biotechnologies, Inc. Cambridge, MA 02140 (US)

(72) Inventors: ALFONSE, Lauren E. Cambridge, Massachusetts 02140 (US) JAKIMO, Noah M. Cambridge, Massachusetts 02140 (US) MABEN, Zachary J. Cambridge, Massachusetts 02140 (US) TORGERSON, Chad D. Cambridge, Massachusetts 02140 (US) WATTERS, Kyle E. Cambridge, Massachusetts 02140 (US) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)